Product name：TERT-BUTYL 5-OXO-2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE
Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthetic route is as follows:
Reactants are commercially availlable.
Slade, David J., US2011/144150, A1, (2011) In a method analogous to J.Malpass and C. Cox, Tetrahedron Lett., 1999, 40, 1419-1422, tert-butyl 2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate is treated with diborane to afford a mixture of alcohols w hich is separated by chromatography.The desired alcohol tert-butyl 5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate is then oxidized using the Swern procedure to afford the title compound.