Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthesis process is as follows:
trichlorophosphate; sodium hydrogencarbonate; N,N-dimethyl-formamide; water; N,N-dimethyl-formamide;
Reactants are commercially availlable.
SHACHAM, Sharon, WO2011/109799, A1, (2011) Synthesis of intermediate (3)E 0 In a 3-neck 100 mL round-bottomed flask, Intermediate 2 ( 4. 8 g, 1 eq.) was dissolved in DMF (20 mL, 5 Vol) and reaction mixture was cooled at 0 °C and POCI3 (8 .5 mL, 4 eq.) was added dropwise in reaction mixture and reaction mixture was stirred at 60 °C for 3 0 min. Reaction completion was monitored on TLC using ethyl acetate: n-hexane (3:7) as mobile phase. Reaction mixture was brought to room temperature and poured into the ice water (500 mL) and adjusted PH 7 using sodium bicarbonate. Compound was extracted in the Ethylacetate(200 mL x 3). Organic lay er was again washed with water (200 mL x 3) followed by drying using anhydrous sodium sulphate. Organic layer was concentrated under reduced pressure to afford 3.0 g of crude compound. Crude product w as purified by flash chromatography using ethyl acetate and hexane as mobile phase to obtain 2.88 g pure compound Yield (65.74percent).