Product name:3,4,5-Trimethoxyaniline
Cas No.:24313-88-0


Product use:Basic raw materials, organic intermediates, pharmaceutical intermediates

The synthesis process is as follows:

triphenylphosphine; tetrahydrofuran;

Reactants are commercially availlable.
Peerce, Brian E., US2003/162753, A1, (2003), |7116610, Patent, Board of Regents, The University of Texas System, US6355823, B1, (2002) Example 7 Synthesis of NHPP from Dimethoxyphenol 2 g of dry 3,5-dimethoxyphenol was dissolved in 25 mL dry THF and cooled in an ice bath. To this solution was added 2.25 g of diethylazodicarboxylate ( DEAD), 6 g of triphenylphosphine and 1 mL of ammonium chloride (NH4Cl). The mixture was stirred for 20 minutes. The mixture was warmed to room temperature and stirred for an additional 30 minutes. S ilica gel was added to remove DEAD, triphenylphosphine, and excess ammonia, yielding 3,5-dimethoxyaniline.