Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthetic route is as follows:
acetic acid; sodium nitrite; water;
Reactants are commercially availlable.
KIM, Myeong-Seop, WO2010/127855, A1, (2010) To a stirred solution of step-a-c product (10 g, 0.065 mol) in acetic acid (470 ml, 47 times), a solution of sodium nitrite (1.54 g, 0.06 mol, 1.1 eq) in water (9 ml) was added and the reaction mass was stirred for 30 - 45 min. Progress of the reaction was monitored by TLC (30percent ethyl acetate/hexane, Rr-0.7). On completion of the reaction, acetic acid was distilled off and the residue obtained was taken in ice water (200 ml). Solid formed was filtered, washed with cold w ater and dried to yield the required product as an yellow colored solid (10 g, 98percent yield).