Product name：3-fluoropyrrolidine hydrochloride
Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthesis process is as follows:
Reactants are commercially availlable.
NOVARTIS PHARMA GMBH, WO2004/69256, A1, (2004) To a solution of 3-(R)-HYDROXY-PYRROLIDINE-1-CARBOXYLIC acid ter-butyl ester (200mg) in CH2CI2 (1 OML) is added [bis (2-methoxyethyl) amino] sulfer trifluoride (236uL) at 0C, and stirred for 1HR at ro om temperature. The reaction mixture is poured in aqueous NaHC03 and extracted with Et20. The organic layer is successively washed with H20 and aqueous NACI, dried over MGS04, and concentrated in vacu o. The residue is purified by column chromatography to give a colorless oil. The oil is dissolved in 4N HCI in dioxane (5mL) and stirred for 1. 5hr at room temperature. The reaction mixture is concent rated in vacuoto provide the title compound.