Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthesis process is as follows:
Reactants are commercially availlable.
Stein, Philip D., US2004/186134, A1, (2004)  Part C: To a solution of 1,1-dimethylethyl 3,3-difluoropyrrolidine-1-carboxylate (0.868 g, 4.19 mmol) in 1.5 mL of 1,4-dioxane was added a solution of hydrogen chloride in 1,4-dioxane (4 M, 11 mL, 44 mmol) at 0°C. The mixture was stirred at 0°C. for 40 min, at room temperature for 1 h a nd was then concentrated to afford 0.65 g (100percent) of 3,3-difluoropyrrolidine hydrochloride: 1H- NMR (CD3OD) delta 3.54 (2H, t, J=11.9 Hz), 3.43 (2H, t, J=7.8 Hz), 2.40 (2H, m).