Product name：Benzonitrile, 5-formyl-2-methyl- (9CI)
Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthetic route is as follows:
manganese(IV) dioxide; chloroform;
Reactants can be synthesized in 1 step.
Abbott Laboratories, US6593335, B1, (2003) EXAMPLE 154C 3-cyano-4-methylbenzaldehyde Example 154B (1.4 g, 10 mmol) in chloroform (30 mL) was treated with manganese dioxide (3.3 g, 40 mmol). The reaction mixture was stirred at room temperature for 12 hours, filtered, the solvent evaporated and the crude residue purified by flash chromatography over silica gel eluding with ethyl acetate:hexane (5:95) to provide 0.9 g of the title compound. 1 H NMR (CDCI3) 6 2.67 (s, 3H), 7.48 (dd, 1H), 8.0 (dd, 1H), 10.0 (s, 1H).