Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthetic route is as follows:
Reactants are commercially availlable.
Lyle, Terry Alan, US2003/158218, A1, (2003) A mixture of 7.5660 g (45.25 mmol) 4-hydroxy-2-(methylthio)pyrimidine-5-carbonitrile and 40 mL (429. 14 mmol) of phosphorus oxychloride was heated at 110°C. for 3.5 h and then concentrated in vacuo. T o the resulting residue was added and decanted boiling hexane (60 mL*4). The combined hexane fractions were concentrated in vacuo to give of 4-chloro-2-(methylthio)pyrimidine-5-carbonitrile as a yello w solid. 1H NMR (CDCl3, 400 MHz) delta 8.645 (s, 1H, ArH); 2.625 (s, 3H, CH3); MS ES+M+1=186.0