Product name:4-Bromo-3-hydroxybenzoic acid
Cas No.:14348-38-0


Product use:Basic raw materials, organic intermediates, pharmaceutical intermediates

The synthesis process is as follows:

bromine; acetic acid; ethanol;

Reactants are commercially availlable.
ABBOTT LABORATORIES, WO2005/23762, A1, (2005) Example 56 (2S)-1-{(5R)-5-((5-carboxy-2-bromophenoxy)-methyl)-L-prolyl}-pyrrolidine-2- carbonitrile Example 56A 4-Bromo-3-hydroxy-benzoic acid Bromine (0.37 mL, 7.2 mmol) was added to 3-hydroxy-benzoi c acid (500 mg, 3.6 mmol) in ethanol (2 ML) and acetic acid (1 mL). The mixture was stirred at room temperature for 30 min and then concentrated and purified by column chromatography to give the produ ct (314 mg, 40 percent). MS (DCI) m/z 234 (M+NH4) +.