Product name:cis-3-(Boc-aMino)-5-(trifluorMethyl)piperidine
MF:C11H19F3N2O2

MW: 268.28
Cas No.:1187055-62-4
Structure:

Purity:97%

Product use:Basic raw materials, organic intermediates, pharmaceutical intermediates

The synthetic route is as follows:

hydrogen; acetic acid; platinum(IV) oxide; 5 rhodium-on-charcoal

Reactants can be synthesized in 1 step.
Tetalman, Michelle, US2010/216839, A1, (2010) To a solution of tert-butyl 5-(trifluoromethyl)pyridin-3-ylcarbamate (3 g, 14 mmol) in glacial acetic acid (50 mL) was added 5percent Rhodium on active carbon (0.5 g) and Platinum(IV) oxide (0.5 g) in the hydrogenation steel bomb. The mixture was sealed and hydrogenated at 200 psi and 70°C. for 48 h. the mixture was filtered through Celite and concentrated to give cis-(+/-)-tert-butyl 5-(trifluor omethyl)piperidin-3-ylcarbamate. LCMS (m/z): 269.1 (MH+).