Product name：tert-butyl N-[endo-8-azabicyclo[3.2.1]octan-3-yl]carbamate
Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthesis process is as follows:
sodium hydroxide; formic acid; methanol; palladium monocarbide
Reactants can be synthesized in 1 step.
Nippon Shinyaku Co., Ltd., EP1156045, A1, (2001) Reference Example 17 3-(tert-Butoxycarbonylamino)-8-azabicyclo[3.2.1]octane 8-Benzyl-3-(tert-butoxycarbonylamino)-8-azabicyclo [3.2.1]octane was dissolved in 400 ml of methanol followed by adding form ic acid (25.80 g) and 10percent palladium carbon (5 g). The mixture was stirred at room temperature for 16 hours. Then, the catalyst was removed by filtration. The mother liquor was alkalized by addi ng an aqueous solution of sodium hydroxide, which was extracted with chloroform. The organic layer was dried and concentrated. The residue was purified by column chromatography on silica gel (chlorofo rm: methanol = 5:1) to provide brown oil (12 g).