Product name：ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
Appearance: Yellow solid
Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthetic route is as follows:
iso-butyl nitrite; trimethylsilyl bromide; ethyl acetate; acetonitrile;
Reactants are commercially availlable.
GLAXO GROUP LIMITED, WO2004/6923, A1, (2004) TO A SOLUTION OF 2-METHYL-1-NITROSOOXY-PROPANE (28.2 ML, 2.1 EQ. ) IN CH3CN (700 ML) COOLED TO 0XB0;C WAS ADDED DROPWISE BROMO-TRIMETHYL-SILANE (32 ML, 2.1 EQ. ). THE] resulting mixture was maintained at [0XB0;C.] A solution of the available 2-amino-4- methyl-thiazole-5-carboxylic acid ethyl ester (18.6 g, 0.1 mol) in CH3CN/AcOEt 75/25 was added dropwise and the reaction mixture was maintained at [0XB0;C.] The mixture was stirred for 24 hours at rt. The solvent was evaporated and water was added. The product was extracted with AcOEt, dried over [NA2SO4,] filtered and evaporated. The title comp ound was obtained as a yellow solid (21.74 g, 87 [MMOL)] in 87percent yield after purification by flash chromatography using DCM as eluent ; GC/MS: [M'C7H8BRNO2S] 250.