Product name：(2-METHYL-THIAZOL-4-YL)-ACETIC ACID
Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthesis process is as follows:
potassium hydroxide; hydrochlorid acid; tetrahydrofuran; water; water;
Reactants are commercially availlable.
WO2005/9941, A1, (2005) Prepare a solution of (2-methylthiazpl-4-yl) acetic acid ethyl ester (17 g, 92 mmol) T in tetrahydrofuran/water (1: 1,400 mL). Add potassium hydroxide (10.3 g, 184 mmol). hour. Concentrate the solutio n in vacuo to remove the tetrahydrofuran then acidify with IN HCI. Extract the aqueous solution with CHCL3 Wash the resulting organic phase with brine (200 mL), dry (NA2SO4), filter and concentrate in vacuo to afford (2-methylthiazol-4-yl) acetic acid (11.3 g) as a SOLID. H NMR (CDC13) 8 7.00 (s, 1H), 3.85 (s, 2H), 2.71 (s, 3H).