Appearance：off white solid
Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthesis process is as follows:
Reactants are commercially availlable.
DESAI, Neil, WO2010/144394, A1, (2010) Example 17Compound 16 (3.0 g, 15.05 mmol) was added to a suspension of thiourea (1.4 g, 18.10 mmol) in ethanol. The reaction mixture was refluxed for 8h. After cooling, solvent was concentrated and re sidue was subjected to purification with DCM/MeOH to give 17 as yellow solid (2.3 g, 80percent). 1H NMR (400 MHz, DMSO-d6) delta 9.37 (bs, 2H, NH2), 7.82 (s,1Eta, Ar-H), 7.58-7.34 (m, 6Eta, Ar-H); ESI -MS: calcd for (C9Eta8N2S) 176, found 177[M+H] .