Product name:(Bromomethyl)cyclopropane
Cas No.:7051-34-5


Product use:Basic raw materials, organic intermediates, pharmaceutical intermediates

The synthesis process is as follows:

bromine; triphenylphosphine; N-methylacetamide;

Reactants are commercially availlable.
Bayer Aktiengesellschaft, US6008420, A1, (1999) Example 1 (for comparison) 1250 ml of dimethylformamide were placed into the reaction vessel, and then 280.8 g of triphenylphosphine and then 70 g of hydroxymethylcyclopropane were added, the mixture was stirred for 30 minutes at room temperature under a nitrogen atmosphere, and the solution was sub sequently cooled to -10°C. Then, 158.3 g of bromine (that is to say 2 mol percent more than theoret ically required) were metered in in the course of 4 hours. The reaction mixture was worked up by distillation. Bromomethylcyclopropane was obtained in a yield of 77.5percent of theory. The purity of the product was over 97percent, the open-chain halogenoalkanes amounted to 0.6percent.