Product name:tert-Butyl 6-Hydroxyhexanoate
Cas No.:73839-20-0


Appearance:colorless liquid

Product use:Basic raw materials, organic intermediates, pharmaceutical intermediates

The synthesis process is as follows:

potassium tert-butylate; dichloromethane;

Reactants are commercially availlable.
KUNZ, Arthur, WO2015/187596, A2, (2015) To a 250 mL round bottom flask equipped with a magnetic stirrer, thermocouple, condenser and nitrogen inlet was charged 6-hexanolactone 14 (3.7 g; 32 mmol) and i-BuOH (100 mL) in DCM followed by i-BuO K (3.9 g; 35 mmol; 1.1 equiv.). This solution was stirred and heated to reflux for 3 hours. The solution was diluted with toluene, washed with water and brine, dried over Na2S04, filtered and concentr ated to afford 4.8 g (80percent yield) as a clear yellow oil. 1H-NMR (500 MHz, CDC13): delta 3.65 - 3.62 (m, 2H), 2.32 - 2.29 (m, 1H), 2.23 - 2.20 (m, 2H), 1.66 - 1.55 (m, 4H), 1.43 (s, 9H), 1.41 - 1. 35 (m, 2H).