Product name:3-BroMopyridine-2-thiol
Cas No.:65938-86-5


Appearance:yellow solid

Product use:Basic raw materials, organic intermediates, pharmaceutical intermediates

The synthesis process is as follows:

sodium sulfide; water; DMFA;

Reactants are commercially availlable.
CHEN, Chixu, WO2011/159839, A2, (2011) [00287] Step C: 3-bromopyridine-2-thiolA mixture of 3-bromo-2-chloropyridine (0.769g, 4mmol) and sod ium sulfide (0.336g, 6mmol) in DMF (3mL) was heated under microwave irradiation at 130°C for 0.5 hou r. Water (50mL) and ethyl acetate (20mL) were added and the layers separated. The aqueous layer was acidified to pH 6 resulting in the formation of a precipitate, which was isolated by filtration and dried under vacuum to yield the product as a yellow solid (0.42g, 55percent).